Intravenous and subcutaneous immune globulin replacement (IVIG and SCIG) are therapies used to treat certain immune deficiencies in which the body does not produce enough protective antibodies. Immune globulin is made from donated human plasma and contains a broad range of antibodies that help the immune system fight infections. These treatments do not stimulate the immune system; instead, they replace missing antibodies, providing passive protection and helping reduce the frequency and severity of infections.
IVIG is given through a vein, usually every 3–4 weeks, while SCIG is administered under the skin on a weekly or more frequent schedule, often at home after training. The choice between IVIG and SCIG depends on medical needs, lifestyle, and patient preference. Both forms are generally well-tolerated and have a long safety record. Ongoing monitoring and dose adjustments are guided by infection history, blood antibody levels, and overall response to therapy, with the goal of improving immune protection and quality of life.
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